ATS 2007 Abstracts:

• Canine IT-HCL Induced Acute Lung Injury Does Not Alter Renal Function Early in the Course of Injury
• Inactivation of hypoxic pulmonary vasoconstriction results in acute increase in extravascular lung water measurement by PiCCO in canine acute lung injury
• Charaterization of Bronchoalveolar Fluid (BALF) after treatment with rSP-C surfactant in severe ovine LPS-induced acute lung injury (ALI)

ATS 2006 Abstracts:

• Regional Lung Behavior Measured by Parenchymal Markers and CT Imaging in Ovine Acute Lung Injury
• Characterization of the Evolution of Sheep LPS Acute Lung Injury (ALI) by Functional CT Imaging
• Recirculation of Inhaled Xenon does not Alter Lung CT Density

ATS 2005 Abstracts:

• Ventilation (V), Perfusion (Q) and V/Q Quantification of the Ovine Lung using Functional
  CT Imaging
• rSP-C Surfactant Improves Oxygenation and Shunt in Severe Ovine LPS-Induced
  Acute Lung Injury (ALI)
• Regional V-Q Distribution is More Uniform at Apex and in the Prone Position Measured by MDCT
• Sphingosine 1-Phosphate (S1P) Rescues an Endotoxin (LPS) Model of Canine Lung Injury
• The effect of endotracheal tube diameter on tidal volume delivery during high frequency oscillatory ventilation (HFOV)
• Gene Expression Analysis of Systemic Versus Local Effects of Ventilation Induced Lung Injury in Canine Model

RSNA 2004 Abstracts:

• CT Measured Regional Specific Compliance Reflects Regional Ventilation in Supine Sheep

ATS 2004 Abstracts:

• Regional Specific Compliance as a Surrogate Measure for Regional Specific Ventilation in Supine Sheep
• Quantifying Mechanical Heterogeneity in Canine Acute Lung Injury (ALI)
• Regional bronchioalveolar lavage (BAL) in a saline lavage model of acute lung injury (ALI) demonstrates regional differences in surfactant behavior
• Sphingosine 1-phosphate reduces regional alveolar edema formation in a canine model of LPS-mediated acute lung injury
• Tidal volume measurement during simulated high frequency oscillatory ventilation
  (HFOV)
• Pre-B-cell colony-enhancing factor (PBEF) is a novel candidate gene in acute lung
  injury
  

• Defining High-frequency oscillatory ventilation in a model of canine ALI/ARDS
• Surfactant mitigation of Lung Injury and Regional Lung Mechanics in a sheep model of ALI/ARDS
• Regional Variants in genomic expression in a unique model of canine of VALI
• 3D Ovine Airwary Tree Rendering for Virtual Bronchoscopy
  Movie was created using the Virtual Navigator software from the laboratory of Bill Higgins at Penn State University.
  • Note: Quicktime Required, get it HERE

Publications:

• *NEW* Effects of acid aspiration-induced acute lung injury on kidney function
• *NEW* Impact of Positive End-Expiratory Pressure During Heterogeneous Lung Injury: Insights from Computed Tomographic Image Functional Modeling
• *NEW* CT-measured regional specific volume change reflects regional ventilation in supine sheep
• Reliability of Estimating Stochastic Lung Tissue Heterogeneity from Pulmonary Impedance Spectra: A Forward-Inverse Modeling Study
• Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations
• Tidal volume delivery during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome
  • Editorial: High-frequency oscillation: How high should we go?
• Relationship between dynamic respiratory mechanics and disease heterogeneity in sheep lavage injury
  • Editorial: PEEP in the morning, PEEP at night
• Effect of low-xenon and krypton supplementation on signal/noise of regional CT-based ventilation measurements
• Characterization of the Interstitial Lung Diseases via Density-Based and Texture-Based Analysis of Computed Tomography Images of Lung Structure and Function
• Regional Ventilation and Lung Mechanics Using X-Ray CT
• Computed Tomography Studies of Lung Mechanics
• A Structural and Functional Assessment of the Lung via Multidetector-Row Computed Tomography
• Recirculation of Inhaled Xenon Does Not Alter CT Lung Density
• Regional Pulmonary Blood Flow in Dogs by 4D-X-Ray CT
• Microarray Analysis of Regional Cellular Responses to Local Mechanical Stress in Acute Lung Injury
  • Online Data Supplement
• Four Methods of Measuring Tidal Volume During High-Frequency Oscillatory Ventilation
• Mechanism of Hypoxemia in Acute Lung Injury Evaluated by Multidetector-Row CT
• Biologic Variability in Mechanical Ventilation Rate and Tidal Volume Does Not Improve Oxygenation or Lung Mechanics in Canine Oleic Acid Lung Injury
• Changes in regional lung mechanics and ventilation distribution after unilateral pulmonary artery occlusion
• Elective endothelial dysfunction in conscious dogs after cardiopulmonary bypass
• Distribution of pulmonary ventilation using Xe-enhanced computed tomography in prone and supine dogs
• Parameter estimation and confidence intervals for Xe-CT ventilation studies: a Monte Carlo approach
• A comprehensive equation for the pulmonary pressure-volume curve
• Effect of hypoxia on respiratory system impedance in dogs
• CT-based assessment of regional pulmonary microvascular blood flow parameters
• Non-Invasive imaging of regional lung function using x-ray computed tomography.
• Mean airway pressure and alveolar pressure during high-frequency ventilation.
• Design and calibration of a high-frequency oscillatory ventilator
• High-Frequency Ventilation for Acute Lung Injury and ARDS
  • Comment to Editor
• Pressure-Volume Curve Does Not Predict Steady-State Lung Volume in Canine Lavage Lung Injury
• Sphingosine 1-Phosphate Reduces Vascular Leak in Murine and Canine Models
• Sphingosine 1-Phosphate Reduces Vascular Leak in Murine and Canine Models of Acute Lung Injury
  • ONLINE DATA SUPPLEMENT
  • Lung Injury Sphingosine-1-Phosphate to the Rescue EDITORIAL
• Pre-B-cell colony enhancing factor as a potential novel biomarker in acute lung injury
• The Comprehensive Imaging-Based Analysis of the Lung: A Forum for Team Science
• Molecular Cloning and Characterization of Canine Pre-B-Cell Colony-Enhancing Factor
• In vitro identification and in silico utilization of interspecies sequence similarities using GeneChip® technology
• Totally endoscopic robot-assisted transmyocardial revascularization
• Estimation of regional lung expansion via 3D image registration
• Xenon gas flow patterns evaluated by high speed multi-row detector CT
• Differences in regional wash-in and wash-out time constants for Xe-CT ventilation studies
• Quantifying Mechanical Heterogeneity in Canine Acute Lung Injury